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Assay Detail

CHEMBL765660

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Binding
Binding affinity towards progesterone receptor was measured
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones.
Zhang P, Terefenko EA, Wrobel J, Zhang Z, Zhu Y, Cohen J, Marschke KB, Mais D.
Bioorg Med Chem Lett (2001) 11 : 2747 -2750
PubMed 11591515 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.81 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1276308 MIFEPRISTONE 4.0 1 8.96
CHEMBL93027 1 7.70
CHEMBL93906 1 7.52
CHEMBL94053 1 6.90
CHEMBL316078 1 6.82
CHEMBL315445 1 6.48
CHEMBL329631 1 6.28
CHEMBL327444 1 6.28
CHEMBL92026 1 6.28
CHEMBL327409 1 6.15
CHEMBL94162 1 5.50
CHEMBL313850 1 -
CHEMBL328332 1 -
CHEMBL92354 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1276308 MIFEPRISTONE Ki = 1.1 nM 8.96
CHEMBL93027 Ki = 20.0 nM 7.70
CHEMBL93906 Ki = 30.0 nM 7.52
CHEMBL94053 Ki = 127.0 nM 6.90
CHEMBL316078 Ki = 150.0 nM 6.82
CHEMBL315445 Ki = 332.0 nM 6.48
CHEMBL329631 Ki = 525.0 nM 6.28
CHEMBL327444 Ki = 525.0 nM 6.28
CHEMBL92026 Ki = 521.0 nM 6.28
CHEMBL327409 Ki = 714.0 nM 6.15
CHEMBL94162 Ki = 3127.0 nM 5.50
CHEMBL313850 Ki > 10000.0 nM -
CHEMBL328332 Ki ~ 1000.0 nM -
CHEMBL92354 Ki > 10000.0 nM -