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Assay Detail

CHEMBL765843

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Binding
Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptor
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a novel class of nonsteroidal progesterone receptor agonists: effect of A-ring modification.
Zhi L, Tegley CM, Marschke KB, Mais DE, Jones TK.
J Med Chem (1999) 42 : 1466 -1472
PubMed 10212133 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 8.26 9.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL416411 1 9.49
CHEMBL717 MEDROXYPROGESTERONE ACETATE 4.0 1 9.47
CHEMBL286446 1 9.36
CHEMBL286595 1 9.15
CHEMBL32812 1 9.08
CHEMBL35429 1 8.89
CHEMBL36564 1 8.59
CHEMBL34824 1 8.46
CHEMBL32603 1 8.31
CHEMBL34589 1 8.28
CHEMBL34882 1 8.20
CHEMBL284475 1 8.18
CHEMBL286822 1 8.00
CHEMBL33909 1 7.98
CHEMBL36065 1 7.78
CHEMBL34015 1 7.67
CHEMBL286662 1 7.61
CHEMBL35525 1 7.55
CHEMBL285705 1 7.54
CHEMBL36076 1 7.04
CHEMBL286158 1 6.91
CHEMBL35431 1 -
CHEMBL34035 1 -
CHEMBL286130 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL416411 Ki = 0.32 nM 9.49
CHEMBL717 MEDROXYPROGESTERONE ACETATE Ki = 0.34 nM 9.47
CHEMBL286446 Ki = 0.44 nM 9.36
CHEMBL286595 Ki = 0.7 nM 9.15
CHEMBL32812 Ki = 0.83 nM 9.08
CHEMBL35429 Ki = 1.3 nM 8.89
CHEMBL36564 Ki = 2.6 nM 8.59
CHEMBL34824 Ki = 3.5 nM 8.46
CHEMBL32603 Ki = 4.9 nM 8.31
CHEMBL34589 Ki = 5.3 nM 8.28
CHEMBL34882 Ki = 6.3 nM 8.20
CHEMBL284475 Ki = 6.6 nM 8.18
CHEMBL286822 Ki = 10.1 nM 8.00
CHEMBL33909 Ki = 10.5 nM 7.98
CHEMBL36065 Ki = 16.6 nM 7.78
CHEMBL34015 Ki = 21.3 nM 7.67
CHEMBL286662 Ki = 24.6 nM 7.61
CHEMBL35525 Ki = 28.0 nM 7.55
CHEMBL285705 Ki = 28.6 nM 7.54
CHEMBL36076 Ki = 91.0 nM 7.04
CHEMBL286158 Ki = 123.0 nM 6.91
CHEMBL35431 Ki > 500.0 nM -
CHEMBL34035 Ki > 500.0 nM -
CHEMBL286130 Ki = - nM -