Compound Detail
CHEMBL286662
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Basic Information
| ChEMBL ID | CHEMBL286662 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ULQQAJOXIKLWSL-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
389.9
MW (Da)
6.27
ALogP
3
HBA
1
HBD
38.3
PSA (Ų)
0.53
QED
1
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.42
Ki 1 meas. best 7.61
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | Ki | 7.61 | 7.61 | 24.6 | 1 |
| Progesterone receptor CHEMBL208 | IC50 | 6.42 | 6.42 | 376.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | Ki | = | 24.6 | nM | 7.61 | Compound was evaluated for its binding affinity against baculovirus expressed Pr... | 10212133 |
| Progesterone receptor | IC50 | = | 376.0 | nM | 6.42 | Antagonistic activity by cotransfection assay against human Progesterone recepto... | 10212133 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10212133 | 10.1021/jm980723h | Progesterone receptor | 3 |
Data from ChEMBL 36 via Core Engine