Assay Detail
Functional
CHEMBL768811
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a novel class of nonsteroidal progesterone receptor agonists: effect of A-ring modification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.09 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33909 | — | — | 1 | 6.85 |
| CHEMBL286662 | — | — | 1 | 6.42 |
| CHEMBL34035 | — | — | 1 | 6.34 |
| CHEMBL286595 | — | — | 1 | 6.22 |
| CHEMBL286130 | — | — | 1 | 5.76 |
| CHEMBL36076 | — | — | 1 | 5.51 |
| CHEMBL35431 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33909 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL286662 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL34035 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL286595 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL286130 | — | IC50 | = | 1755.0 | nM | 5.76 |
| CHEMBL36076 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL35431 | — | IC50 | = | 3200.0 | nM | 5.50 |