Assay Detail
Functional
CHEMBL766559
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for vasorelaxant activity determined using potassium-depolarized rabbit thoracic aorta
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dihydropyrimidine calcium channel blockers 51: bicyclic dihydropyrimidines as potent mimics of dihydropyridines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.44 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97969 | — | — | 1 | 8.82 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.60 |
| CHEMBL440695 | — | — | 1 | 8.52 |
| CHEMBL328206 | — | — | 1 | 8.30 |
| CHEMBL102137 | — | — | 1 | 8.15 |
| CHEMBL99930 | — | — | 1 | 8.00 |
| CHEMBL101703 | — | — | 1 | 7.68 |
| CHEMBL101608 | — | — | 1 | 7.64 |
| CHEMBL100511 | — | — | 1 | 7.27 |
| CHEMBL317386 | — | — | 1 | 7.02 |
| CHEMBL101582 | — | — | 1 | 6.50 |
| CHEMBL99264 | — | — | 1 | 6.21 |
| CHEMBL317153 | — | — | 1 | 5.94 |
| CHEMBL545263 | — | — | 1 | 5.54 |
| CHEMBL99329 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97969 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL440695 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL328206 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL102137 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL99930 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL101703 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL101608 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL100511 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL317386 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL101582 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL99264 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL317153 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL545263 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL99329 | — | IC50 | > | 1000.0 | nM | - |