Assay Detail
Functional
CHEMBL766869
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Inhibition of rabbit platelet aggregation induced by PAF (Platelet activating factor)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Diketopiperazines as a new class of platelet-activating factor inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.80 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2115424 | — | — | 1 | 6.75 |
| CHEMBL297624 | — | — | 1 | 6.50 |
| CHEMBL2368940 | — | — | 1 | 6.43 |
| CHEMBL2115428 | — | — | 1 | 6.16 |
| CHEMBL2114975 | — | — | 1 | 5.72 |
| CHEMBL46123 | — | — | 1 | 5.64 |
| CHEMBL2114979 | — | — | 1 | 5.44 |
| CHEMBL2114974 | — | — | 1 | 5.10 |
| CHEMBL2115423 | — | — | 1 | 4.44 |
| CHEMBL3351045 | — | — | 1 | - |
| CHEMBL3350358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2115424 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL297624 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2368940 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2115428 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2114975 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL46123 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2114979 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2114974 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2115423 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3351045 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL3350358 | — | IC50 | = | 140000.0 | nM | - |