Assay Detail
Functional
CHEMBL767381
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Potency of the Angiotensin II-induced contraction of rabbit aortic strips
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery and development of aryl-fused imidazole-based angiotensin II antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 29 | 7.76 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309145 | — | — | 1 | 8.90 |
| CHEMBL70144 | — | — | 1 | 8.90 |
| CHEMBL71162 | — | — | 1 | 8.70 |
| CHEMBL66229 | — | — | 1 | 8.70 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.60 |
| CHEMBL69824 | — | — | 2 | 8.50 |
| CHEMBL70016 | — | — | 1 | 8.30 |
| CHEMBL69831 | — | — | 1 | 8.30 |
| CHEMBL262931 | — | — | 1 | 8.30 |
| CHEMBL302509 | — | — | 1 | 8.10 |
| CHEMBL302101 | — | — | 1 | 8.10 |
| CHEMBL303643 | — | — | 1 | 8.00 |
| CHEMBL303271 | — | — | 1 | 8.00 |
| CHEMBL71276 | — | — | 1 | 8.00 |
| CHEMBL68767 | — | — | 1 | 7.70 |
| CHEMBL69736 | — | — | 1 | 7.70 |
| CHEMBL69898 | — | — | 1 | 7.60 |
| CHEMBL68525 | — | — | 1 | 7.50 |
| CHEMBL68598 | — | — | 1 | 7.50 |
| CHEMBL69861 | — | — | 1 | 7.40 |
| CHEMBL70189 | — | — | 1 | 7.30 |
| CHEMBL306486 | — | — | 1 | 7.20 |
| CHEMBL69138 | — | — | 1 | 7.20 |
| CHEMBL69906 | — | — | 1 | 7.10 |
| CHEMBL303445 | — | — | 1 | 6.40 |
| CHEMBL69278 | — | — | 1 | 6.30 |
| CHEMBL306893 | — | — | 1 | 6.20 |
| CHEMBL69768 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309145 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL70144 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL71162 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL66229 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL191 | LOSARTAN | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL69824 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL69824 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL70016 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL69831 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL262931 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL302509 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL302101 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL71276 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL303271 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL303643 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL68767 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL69736 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL69898 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL68525 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL68598 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL69861 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL70189 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL306486 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL69138 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL69906 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL303445 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL69278 | — | Kd | = | 501.19 | nM | 6.30 |
| CHEMBL306893 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL69768 | — | Kd | = | 794.33 | nM | 6.10 |