Assay Detail

CHEMBL767383

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Functional

Tested for antagonistic activity of compound in endothelium-deprived rabbit pulmonary artery

ChEMBL ↗

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Target

Oryctolagus cuniculus (CHEMBL374) ↗

Open DB target context

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Oryctolagus cuniculus (CHEMBL374) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Oryctolagus cuniculus

CHEMBL374

Anchored from Assay target.

Protein identity Oryctolagus cuniculus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Oryctolagus cuniculus
Confidence	1 — Organism
Curated By	Intermediate

Target

Oryctolagus cuniculus (CHEMBL374) ↗

Type	ORGANISM
Organism	Oryctolagus cuniculus

Publication

Low molecular weight neurokinin NK2 antagonists

Smith P, McElroy A, Pritchard J, Deal M, Ewan G, Hagan R, Ireland S, Ball D, Beresford I, Sheldrick R, Jordan C, Ward P
Bioorg Med Chem Lett (1993) 3 : 931 -936
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	10.30	10.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL308148	SAREDUTANT	3.0	1	10.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL308148	SAREDUTANT	Kd	=	0.05012	nM	10.30