Assay Detail
Functional
CHEMBL767384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory activity against angiotensin II induced contraction in rabbit aortic rings
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Substituted pyrrolidin-2-one biphenyltetrazoles as angiotensin II antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 19 | 7.97 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122891 | — | — | 1 | 9.00 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.80 |
| CHEMBL421094 | — | — | 1 | 8.50 |
| CHEMBL126066 | — | — | 1 | 8.40 |
| CHEMBL121991 | — | — | 1 | 8.40 |
| CHEMBL333324 | — | — | 1 | 8.40 |
| CHEMBL121871 | — | — | 1 | 8.40 |
| CHEMBL332962 | — | — | 1 | 8.30 |
| CHEMBL123208 | — | — | 1 | 8.20 |
| CHEMBL123375 | — | — | 1 | 8.00 |
| CHEMBL123713 | — | — | 1 | 7.90 |
| CHEMBL124449 | — | — | 1 | 7.90 |
| CHEMBL338974 | — | — | 1 | 7.70 |
| CHEMBL123348 | — | — | 1 | 7.60 |
| CHEMBL122389 | — | — | 1 | 7.50 |
| CHEMBL122855 | — | — | 1 | 7.40 |
| CHEMBL125637 | — | — | 1 | 6.60 |
| CHEMBL330866 | — | — | 1 | 6.50 |
| CHEMBL436171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122891 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL191 | LOSARTAN | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL421094 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL126066 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL121991 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL333324 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL121871 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL332962 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL123208 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL123375 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL123713 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL124449 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL338974 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL123348 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL122389 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL122855 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL125637 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL330866 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL436171 | — | Kd | > | 1000.0 | nM | - |