Assay Detail
Functional
CHEMBL767385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the ability to inhibit endothelin-1 (ET-1) induced contraction in rabbit femoral arterial rings.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
-Carbamate butenolide analogues as potent ETA selective endothelin receptor antagonists and prodrugs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.33 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450337 | — | — | 1 | 7.70 |
| CHEMBL8981 | PD-156707 | — | 1 | 7.50 |
| CHEMBL319452 | — | — | 1 | 7.30 |
| CHEMBL322920 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450337 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL8981 | PD-156707 | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL319452 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL322920 | — | Kd | = | 158.49 | nM | 6.80 |