Assay Detail
Functional
CHEMBL767387
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for the inhibition of [Nle10]-NKA(4-10)-induced contraction of the rabbit pulmonary artery
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pharmacological profile and chemical synthesis of SR 48968, a non-peptide antagonist of the neurokinin A (NK2) receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 9.68 | 10.48 |
| pA2 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308148 | SAREDUTANT | 3.0 | 1 | 10.48 |
| CHEMBL173008 | — | — | 1 | 10.17 |
| CHEMBL173841 | — | — | 1 | 9.77 |
| CHEMBL71397 | — | — | 1 | 9.74 |
| CHEMBL176588 | — | — | 1 | 9.64 |
| CHEMBL368995 | — | — | 1 | 9.35 |
| CHEMBL176853 | — | — | 1 | 8.63 |
| CHEMBL173203 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308148 | SAREDUTANT | Kd | = | 0.03311 | nM | 10.48 |
| CHEMBL173008 | — | Kd | = | 0.06761 | nM | 10.17 |
| CHEMBL173841 | — | Kd | = | 0.1698 | nM | 9.77 |
| CHEMBL71397 | — | Kd | = | 0.182 | nM | 9.74 |
| CHEMBL176588 | — | Kd | = | 0.2291 | nM | 9.64 |
| CHEMBL368995 | — | Kd | = | 0.4467 | nM | 9.35 |
| CHEMBL176853 | — | Kd | = | 2.344 | nM | 8.63 |
| CHEMBL173203 | — | pA2 | - | — | - |