Assay Detail
Binding
CHEMBL767417
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Inhibition of Protein kinase C gamma (PKC-gamma)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.74 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91829 | RUBOXISTAURIN | 3.0 | 1 | 6.52 |
| CHEMBL340259 | INDOLYLYLMALEIMIDE 2 | — | 1 | 5.92 |
| CHEMBL340935 | INDOLYLYLMALEIMIDE 1 | — | 1 | 5.87 |
| CHEMBL334555 | — | — | 1 | 5.57 |
| CHEMBL131035 | — | — | 1 | 5.56 |
| CHEMBL336179 | — | — | 1 | 5.48 |
| CHEMBL130774 | — | — | 1 | 5.29 |
| CHEMBL132223 | — | — | 1 | - |
| CHEMBL340776 | — | — | 1 | - |
| CHEMBL131254 | — | — | 1 | - |
| CHEMBL337642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91829 | RUBOXISTAURIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL340259 | INDOLYLYLMALEIMIDE 2 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL340935 | INDOLYLYLMALEIMIDE 1 | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL334555 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL131035 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL336179 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL130774 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL132223 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL340776 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL131254 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL337642 | — | IC50 | > | 10000.0 | nM | - |