Assay Detail
Binding
CHEMBL767467
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Inhibition of Protein kinase C isolated from rat brain
12
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The enantioselective synthesis and antiinflammatory activity of novel aryl-sphingolipid PKC inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.65 | 4.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79776 | — | — | 3 | 4.71 |
| CHEMBL310067 | — | — | 3 | 4.70 |
| CHEMBL432769 | — | — | 3 | 4.70 |
| CHEMBL311207 | — | — | 2 | 4.67 |
| CHEMBL67166 | SPHINGOSINE | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79776 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL310067 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL432769 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL311207 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL79776 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL79776 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL310067 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL432769 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL67166 | SPHINGOSINE | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL310067 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL311207 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL432769 | — | IC50 | = | 28800.0 | nM | 4.54 |