Compound Detail
CHEMBL310067
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL310067 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ORUOIDWPEASRSZ-QQTWVUFVSA-N |
| Parent Compound | CHEMBL312617 |
| Active Moiety | CHEMBL312617 |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
337.5
MW (Da)
3.98
ALogP
4
HBA
3
HBD
66.5
PSA (Ų)
0.42
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Canis familiaris CHEMBL373 | IC50 | 6.0 | 5.9033 | 1000.0 | 3 |
| Protein kinase C (PKC) CHEMBL2094266 | IC50 | 4.7 | 4.6533 | 20100.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Canis familiaris | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of PKC-dependent neutrophil superoxide burst in dogs | - |
| Canis familiaris | IC50 | = | 1300.0 | nM | 5.89 | Inhibition of PKC-dependent neutrophil superoxide burst in dogs | - |
| Canis familiaris | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of PKC-dependent neutrophil superoxide burst in dogs | - |
| Protein kinase C (PKC) | IC50 | = | 20100.0 | nM | 4.7 | Inhibition of Protein kinase C isolated from rat brain | - |
| Protein kinase C (PKC) | IC50 | = | 23000.0 | nM | 4.64 | Inhibition of Protein kinase C isolated from rat brain | - |
| Protein kinase C (PKC) | IC50 | = | 23700.0 | nM | 4.62 | Inhibition of Protein kinase C isolated from rat brain | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(95)00428-V | Protein kinase C (PKC) | 3 |
| - | 10.1016/0960-894X(95)00428-V | Canis familiaris | 3 |
| - | 10.1016/0960-894X(95)00428-V | Mus musculus | 3 |
Data from ChEMBL 36 via Core Engine