Assay Detail
Functional
CHEMBL660004
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PKC-dependent neutrophil superoxide burst in dogs
9
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
The enantioselective synthesis and antiinflammatory activity of novel aryl-sphingolipid PKC inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.73 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310067 | — | — | 3 | 6.00 |
| CHEMBL311207 | — | — | 2 | 5.82 |
| CHEMBL79776 | — | — | 3 | 5.66 |
| CHEMBL67166 | SPHINGOSINE | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310067 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL310067 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL310067 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL311207 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL311207 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL79776 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL79776 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL79776 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL67166 | SPHINGOSINE | IC50 | = | 4200.0 | nM | 5.38 |