Compound Detail
CHEMBL79776
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Basic Information
| ChEMBL ID | CHEMBL79776 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ARPBUQFSRJYAFR-JUDYQFGCSA-N |
| Parent Compound | CHEMBL84654 |
| Active Moiety | CHEMBL84654 |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
331.5
MW (Da)
3.92
ALogP
3
HBA
3
HBD
66.5
PSA (Ų)
0.43
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 5.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Canis familiaris CHEMBL373 | IC50 | 5.66 | 5.6333 | 2200.0 | 3 |
| Protein kinase C (PKC) CHEMBL2094266 | IC50 | 4.71 | 4.6733 | 19500.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Canis familiaris | IC50 | = | 2200.0 | nM | 5.66 | Inhibition of PKC-dependent neutrophil superoxide burst in dogs | - |
| Canis familiaris | IC50 | = | 2400.0 | nM | 5.62 | Inhibition of PKC-dependent neutrophil superoxide burst in dogs | - |
| Canis familiaris | IC50 | = | 2400.0 | nM | 5.62 | Inhibition of PKC-dependent neutrophil superoxide burst in dogs | - |
| Protein kinase C (PKC) | IC50 | = | 19500.0 | nM | 4.71 | Inhibition of Protein kinase C isolated from rat brain | - |
| Protein kinase C (PKC) | IC50 | = | 21800.0 | nM | 4.66 | Inhibition of Protein kinase C isolated from rat brain | - |
| Protein kinase C (PKC) | IC50 | = | 22200.0 | nM | 4.65 | Inhibition of Protein kinase C isolated from rat brain | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(95)00428-V | Mus musculus | 4 |
| - | 10.1016/0960-894X(95)00428-V | Protein kinase C (PKC) | 3 |
| - | 10.1016/0960-894X(95)00428-V | Canis familiaris | 3 |
Data from ChEMBL 36 via Core Engine