Assay Detail
Functional
CHEMBL767566
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell line T47D
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | T47D |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.33 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 10.00 |
| CHEMBL117518 | — | — | 1 | 7.89 |
| CHEMBL117461 | — | — | 1 | 7.87 |
| CHEMBL308938 | — | — | 1 | 7.83 |
| CHEMBL333484 | — | — | 1 | 7.70 |
| CHEMBL117573 | — | — | 1 | 7.69 |
| CHEMBL117187 | — | — | 1 | 7.57 |
| CHEMBL115638 | — | — | 1 | 7.57 |
| CHEMBL117954 | — | — | 1 | 7.55 |
| CHEMBL117067 | — | — | 1 | 7.54 |
| CHEMBL117506 | — | — | 1 | 7.54 |
| CHEMBL326955 | — | — | 1 | 7.54 |
| CHEMBL119058 | — | — | 1 | 7.51 |
| CHEMBL118963 | — | — | 1 | 7.50 |
| CHEMBL118861 | — | — | 1 | 7.44 |
| CHEMBL419057 | — | — | 1 | 7.42 |
| CHEMBL93027 | — | — | 1 | 7.39 |
| CHEMBL324115 | — | — | 1 | 7.25 |
| CHEMBL117965 | — | — | 1 | 7.18 |
| CHEMBL324499 | — | — | 1 | 7.15 |
| CHEMBL331249 | — | — | 1 | 7.07 |
| CHEMBL117612 | — | — | 1 | 7.00 |
| CHEMBL117322 | — | — | 1 | 6.99 |
| CHEMBL117624 | — | — | 1 | 6.89 |
| CHEMBL324156 | — | — | 1 | 6.73 |
| CHEMBL332502 | — | — | 1 | 6.69 |
| CHEMBL117207 | — | — | 1 | 6.64 |
| CHEMBL115903 | — | — | 1 | 6.57 |
| CHEMBL117849 | — | — | 1 | 6.53 |
| CHEMBL118042 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL117518 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL117461 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL308938 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL333484 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL117573 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL117187 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL115638 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL117954 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL117067 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL117506 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL326955 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL119058 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL118963 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL118861 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL419057 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL93027 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL324115 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL117965 | — | IC50 | = | 66.4 | nM | 7.18 |
| CHEMBL324499 | — | IC50 | = | 70.7 | nM | 7.15 |
| CHEMBL331249 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL117612 | — | IC50 | = | 100.1 | nM | 7.00 |
| CHEMBL117322 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL117624 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL324156 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL332502 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL117207 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL115903 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL117849 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL118042 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL332726 | — | IC50 | = | 299.0 | nM | 6.52 |