Compound Detail
CHEMBL117965
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Basic Information
| ChEMBL ID | CHEMBL117965 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WQFMXZOYAIPMFZ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
271.8
MW (Da)
4.24
ALogP
1
HBA
1
HBD
29.1
PSA (Ų)
0.83
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | IC50 | 7.18 | 7.18 | 66.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | IC50 | = | 66.4 | nM | 7.18 | Progesterone receptor antagonist activity based on its ability to block progeste... | 12419390 |
| Progesterone receptor | IC50 | = | 66.0 | nM | 7.18 | Inhibition of human progesterone receptor | 16078826 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12419390 | 10.1016/s0960-894x(02)00746-1 | Progesterone receptor | 1 |
| 16078826 | 10.1021/jm050358b | Progesterone receptor | 1 |
Data from ChEMBL 36 via Core Engine