Assay Detail
Binding
CHEMBL876979
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Inhibition of human progesterone receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.47 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138059 | — | — | 1 | 8.10 |
| CHEMBL136721 | — | — | 1 | 7.82 |
| CHEMBL136806 | — | — | 1 | 7.52 |
| CHEMBL117965 | — | — | 1 | 7.18 |
| CHEMBL329631 | — | — | 1 | 7.14 |
| CHEMBL315445 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138059 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL136721 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL136806 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL117965 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL329631 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL315445 | — | IC50 | = | 84.0 | nM | 7.08 |