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Assay Detail

CHEMBL767886

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Functional
In vitro inhibition of platelet activating factor induced platelet aggregation in rabbit platelet rich plasma.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Tissue Plasma
Confidence 1 — Organism
Curated By Expert

Target

Oryctolagus cuniculus (CHEMBL374)
Type ORGANISM
Organism Oryctolagus cuniculus

Publication

Approach to dual-acting platelet activating factor (PAF) receptor antagonist/thromboxane synthase inhibitor (TxSI) based on the link of PAF antagonists and TxSIs.
Fujita M, Seki T, Inada H, Shimizu K, Takahama A, Sano T.
Bioorg Med Chem Lett (2002) 12 : 341 -344
PubMed 11814792 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.71 7.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29067 1 7.54
CHEMBL323798 1 7.22
CHEMBL2111765 1 7.17
CHEMBL117018 1 7.17
CHEMBL408135 1 7.00
CHEMBL114843 1 6.70
CHEMBL324118 1 6.55
CHEMBL114014 1 6.44
CHEMBL116975 1 6.35
CHEMBL117889 1 6.32
CHEMBL263227 1 6.26
CHEMBL114251 1 6.25
CHEMBL539177 1 6.21
CHEMBL420137 1 -
CHEMBL324533 1 -
CHEMBL117816 1 -
CHEMBL116673 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29067 IC50 = 29.0 nM 7.54
CHEMBL323798 IC50 = 60.0 nM 7.22
CHEMBL2111765 IC50 = 68.0 nM 7.17
CHEMBL117018 IC50 = 68.0 nM 7.17
CHEMBL408135 IC50 = 100.0 nM 7.00
CHEMBL114843 IC50 = 200.0 nM 6.70
CHEMBL324118 IC50 = 280.0 nM 6.55
CHEMBL114014 IC50 = 360.0 nM 6.44
CHEMBL116975 IC50 = 450.0 nM 6.35
CHEMBL117889 IC50 = 480.0 nM 6.32
CHEMBL263227 IC50 = 550.0 nM 6.26
CHEMBL114251 IC50 = 560.0 nM 6.25
CHEMBL539177 IC50 = 610.0 nM 6.21
CHEMBL420137 IC50 > 1000.0 nM -
CHEMBL324533 IC50 > 1000.0 nM -
CHEMBL117816 IC50 > 1000.0 nM -
CHEMBL116673 IC50 > 1000.0 nM -