Assay Detail
Functional
CHEMBL768323
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In vitro cytotoxicity against Raji cell line
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.06 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204195 | — | — | 1 | 5.70 |
| CHEMBL435951 | MITOZOLOMIDE | 2.0 | 1 | 4.41 |
| CHEMBL1442 | MTIC | -1.0 | 1 | - |
| CHEMBL288388 | — | — | 1 | - |
| CHEMBL1204194 | — | — | 1 | - |
| CHEMBL476 | DACARBAZINE | 4.0 | 1 | - |
| CHEMBL287366 | — | — | 1 | - |
| CHEMBL34872 | — | — | 1 | - |
| CHEMBL38014 | — | — | 1 | - |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204195 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL435951 | MITOZOLOMIDE | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1442 | MTIC | IC50 | = | 101000.0 | nM | - |
| CHEMBL288388 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1204194 | — | IC50 | = | 259000.0 | nM | - |
| CHEMBL476 | DACARBAZINE | IC50 | = | 128000.0 | nM | - |
| CHEMBL287366 | — | IC50 | = | 270000.0 | nM | - |
| CHEMBL34872 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL38014 | — | IC50 | = | 435000.0 | nM | - |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | = | 175000.0 | nM | - |