Assay Detail
Binding
CHEMBL768371
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine protein kinase A (PKA)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
cAMP-dependent protein kinase A (CHEMBL2111446) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Bos taurus |
Publication
Structure-based optimization of novel azepane derivatives as PKB inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1202518 | — | — | 1 | 8.70 |
| CHEMBL3216643 | — | — | 1 | 8.30 |
| CHEMBL1202525 | — | — | 1 | 7.41 |
| CHEMBL1204095 | — | — | 1 | 6.44 |
| CHEMBL1202519 | — | — | 1 | 6.10 |
| CHEMBL1204097 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1202518 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3216643 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1202525 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1204095 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1202519 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1204097 | — | IC50 | = | 45000.0 | nM | 4.35 |