Assay Detail
Binding
CHEMBL768431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.61 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313417 | — | — | 1 | 5.27 |
| CHEMBL126023 | — | — | 1 | 4.80 |
| CHEMBL154 | NAPROXEN | 4.0 | 1 | 4.68 |
| CHEMBL96741 | — | — | 1 | 4.29 |
| CHEMBL129761 | — | — | 1 | 4.00 |
| CHEMBL128638 | — | — | 1 | - |
| CHEMBL63135 | — | — | 1 | - |
| CHEMBL14112 | SB-210313 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313417 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL126023 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL154 | NAPROXEN | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL96741 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL129761 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL128638 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63135 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL14112 | SB-210313 | IC50 | > | 100000.0 | nM | - |