Assay Detail
Binding
CHEMBL768493
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Inhibition of the phosphorylation of a random glutamate-tyrosine (4:1) copolymer by isolated mouse Platelet-derived growth factor protein.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL2749) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.12 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57366 | — | — | 1 | 5.96 |
| CHEMBL432738 | — | — | 1 | 5.89 |
| CHEMBL132358 | — | — | 1 | 5.75 |
| CHEMBL133436 | — | — | 1 | 5.58 |
| CHEMBL135889 | — | — | 1 | 5.33 |
| CHEMBL76599 | — | — | 1 | 5.33 |
| CHEMBL135267 | — | — | 1 | 5.11 |
| CHEMBL422797 | — | — | 1 | 4.96 |
| CHEMBL135061 | — | — | 1 | 4.77 |
| CHEMBL58627 | — | — | 1 | 4.68 |
| CHEMBL132089 | — | — | 1 | 4.46 |
| CHEMBL134354 | — | — | 1 | 4.42 |
| CHEMBL339856 | — | — | 1 | 4.35 |
| CHEMBL135074 | — | — | 1 | - |
| CHEMBL299763 | — | — | 1 | - |
| CHEMBL422625 | — | — | 1 | - |
| CHEMBL133604 | — | — | 1 | - |
| CHEMBL134801 | — | — | 1 | - |
| CHEMBL134066 | — | — | 1 | - |
| CHEMBL56942 | — | — | 1 | - |
| CHEMBL134334 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57366 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL432738 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL132358 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL133436 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL135889 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL76599 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL135267 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL422797 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL135061 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL58627 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL132089 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL134354 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL339856 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL135074 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL299763 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL422625 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL133604 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL134801 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL134066 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL56942 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL134334 | — | IC50 | > | 50000.0 | nM | - |