Compound Detail
CHEMBL132089
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Basic Information
| ChEMBL ID | CHEMBL132089 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RFCMDTOLDNJWEN-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
305.2
MW (Da)
3.77
ALogP
4
HBA
2
HBD
77.8
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 6.17 | 6.17 | 680.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 5.55 | 5.55 | 2800.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 4.46 | 4.46 | 35000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 680.0 | nM | 6.17 | Inhibition of the phosphorylation of a random glutamate-tyrosine (4:1) copolymer... | 11063616 |
| Fibroblast growth factor receptor 1 | IC50 | = | 2800.0 | nM | 5.55 | Inhibition of the phosphorylation of a random glutamate-tyrosine (4:1) copolymer... | 11063616 |
| Platelet-derived growth factor receptor beta | IC50 | = | 35000.0 | nM | 4.46 | Inhibition of the phosphorylation of a random glutamate-tyrosine (4:1) copolymer... | 11063616 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11063616 | 10.1021/jm000161d | Fibroblast growth factor receptor 1 | 1 |
| 11063616 | 10.1021/jm000161d | Platelet-derived growth factor receptor beta | 1 |
| 11063616 | 10.1021/jm000161d | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine