Assay Detail
Binding
CHEMBL768513
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Tested for ability to displace [20e3] phorbol 12,13- dibutyrate binding from recombinant bovine Protein kinase C alpha in presence of [Ca2+]
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.94 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334853 | — | — | 1 | 8.74 |
| CHEMBL132720 | — | — | 1 | 8.62 |
| CHEMBL337834 | — | — | 1 | 8.44 |
| CHEMBL133853 | — | — | 1 | 8.25 |
| CHEMBL132612 | — | — | 1 | 7.42 |
| CHEMBL135611 | — | — | 1 | 7.25 |
| CHEMBL336963 | — | — | 1 | 6.81 |
| CHEMBL134413 | — | — | 1 | 6.77 |
| CHEMBL339383 | — | — | 1 | 6.76 |
| CHEMBL337522 | — | — | 1 | 6.68 |
| CHEMBL334195 | — | — | 1 | 6.65 |
| CHEMBL134287 | — | — | 1 | 6.59 |
| CHEMBL448101 | — | — | 1 | 6.56 |
| CHEMBL132525 | — | — | 1 | 6.53 |
| CHEMBL133777 | — | — | 1 | 6.53 |
| CHEMBL335486 | — | — | 1 | 6.50 |
| CHEMBL134690 | — | — | 1 | 6.25 |
| CHEMBL132714 | — | — | 1 | 5.35 |
| CHEMBL334451 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334853 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL132720 | — | Ki | = | 2.39 | nM | 8.62 |
| CHEMBL337834 | — | Ki | = | 3.67 | nM | 8.44 |
| CHEMBL133853 | — | Ki | = | 5.63 | nM | 8.25 |
| CHEMBL132612 | — | Ki | = | 37.9 | nM | 7.42 |
| CHEMBL135611 | — | Ki | = | 56.6 | nM | 7.25 |
| CHEMBL336963 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL134413 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL339383 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL337522 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL334195 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL134287 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL448101 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL132525 | — | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL133777 | — | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL335486 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL134690 | — | Ki | = | 558.0 | nM | 6.25 |
| CHEMBL132714 | — | Ki | = | 4470.0 | nM | 5.35 |
| CHEMBL334451 | — | Ki | = | 7860.0 | nM | 5.11 |