Compound Detail
CHEMBL334195
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Basic Information
| ChEMBL ID | CHEMBL334195 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQHYLMMCTRQCIX-PXNSSMCTSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
375.5
MW (Da)
2.70
ALogP
4
HBA
3
HBD
81.7
PSA (Ų)
0.64
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.65
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C alpha type CHEMBL2213 | Ki | 6.65 | 6.65 | 225.0 | 1 |
| Protein kinase C alpha type CHEMBL299 | Ki | 6.65 | 6.65 | 225.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C alpha type | Ki | = | 225.0 | nM | 6.65 | Tested for ability to displace [20e3] phorbol 12,13- dibutyrate binding from rec... | 12954072 |
| Protein kinase C alpha type | Ki | = | 225.0 | nM | 6.65 | Displacement of PDBU from recombinant Protein kinase C alpha with phosphatidylse... | 12540236 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12954072 | 10.1021/jm0302041 | Protein kinase C alpha type | 1 |
| 12954072 | 10.1021/jm0302041 | No relevant target | 1 |
| 12540236 | 10.1021/jm020350r | No relevant target | 1 |
| 12540236 | 10.1021/jm020350r | Protein kinase C alpha type | 1 |
| 12540236 | 10.1021/jm020350r | AG06848 cell line | 1 |
Data from ChEMBL 36 via Core Engine