Assay Detail
Binding
CHEMBL769625
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Displacement of PDBU from recombinant Protein kinase C alpha with phosphatidylserine
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.60 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330952 | — | — | 1 | 8.25 |
| CHEMBL333323 | — | — | 1 | 8.11 |
| CHEMBL123244 | — | — | 1 | 8.04 |
| CHEMBL123355 | — | — | 1 | 7.95 |
| CHEMBL331344 | — | — | 1 | 7.92 |
| CHEMBL123159 | — | — | 1 | 7.90 |
| CHEMBL6453 | — | — | 1 | 7.83 |
| CHEMBL333240 | — | — | 1 | 7.80 |
| CHEMBL333801 | — | — | 1 | 7.47 |
| CHEMBL334195 | — | — | 1 | 6.65 |
| CHEMBL420170 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330952 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL333323 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL123244 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL123355 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL331344 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL123159 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL6453 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL333240 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL333801 | — | Ki | = | 34.2 | nM | 7.47 |
| CHEMBL334195 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL420170 | — | Ki | = | 1970.0 | nM | 5.71 |