Assay Detail
Binding
CHEMBL768611
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Phosphodiesterase 4B
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.66 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144649 | — | — | 1 | 7.57 |
| CHEMBL144499 | — | — | 1 | 7.20 |
| CHEMBL144823 | — | — | 1 | 7.16 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.66 |
| CHEMBL144491 | — | — | 1 | 6.55 |
| CHEMBL343244 | — | — | 1 | 6.47 |
| CHEMBL423743 | — | — | 1 | 6.35 |
| CHEMBL144633 | — | — | 1 | 6.23 |
| CHEMBL18701 | RO-201724 | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144649 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL144499 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL144823 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL63 | ROLIPRAM | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL144491 | — | Ki | = | 282.0 | nM | 6.55 |
| CHEMBL343244 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL423743 | — | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL144633 | — | Ki | = | 583.0 | nM | 6.23 |
| CHEMBL18701 | RO-201724 | Ki | = | 1930.0 | nM | 5.71 |