Compound Detail
CHEMBL144823
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Basic Information
| ChEMBL ID | CHEMBL144823 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BKNKLCIFIKUCEU-HUUCEWRRSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
317.4
MW (Da)
3.32
ALogP
4
HBA
0
HBD
48.0
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | Ki | 7.16 | 7.16 | 70.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B | Ki | = | 70.0 | nM | 7.16 | Inhibition of human Phosphodiesterase 4B | 7490734 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7490734 | 10.1021/jm00024a012 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
Data from ChEMBL 36 via Core Engine