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Assay Detail

CHEMBL768658

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Calmodulin Sensitive Phosphodiesterase 1 from pig coronary artery
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Tissue Coronary artery
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Phosphodiesterase 1 (CHEMBL2095150)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Inhibition of cyclic nucleotide phosphodiesterases from pig coronary artery by benzo-separated analogues of 3-isobutyl-1-methylxanthine.
Schneller SW, Ibay AC, Martinson EA, Wells JN.
J Med Chem (1986) 29 : 972 -978
PubMed 2423691 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.93 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL175238 1 5.92
CHEMBL177336 1 5.75
CHEMBL277529 1 5.72
CHEMBL26606 1 5.36
CHEMBL366545 1 5.31
CHEMBL307639 1 5.28
CHEMBL275084 ISOBUTYLMETHYLXANTHINE 1 5.20
CHEMBL309026 1 5.08
CHEMBL367399 1 4.82
CHEMBL171957 1 4.72
CHEMBL175370 1 4.70
CHEMBL367083 1 4.44
CHEMBL366822 1 4.44
CHEMBL306389 1 4.40
CHEMBL175132 1 4.39
CHEMBL175958 1 4.27
CHEMBL20613 1 4.07
CHEMBL369824 1 -
CHEMBL173998 1 -
CHEMBL175489 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL175238 IC50 = 1200.0 nM 5.92
CHEMBL177336 IC50 = 1800.0 nM 5.75
CHEMBL277529 IC50 = 1900.0 nM 5.72
CHEMBL26606 IC50 = 4400.0 nM 5.36
CHEMBL366545 IC50 = 4900.0 nM 5.31
CHEMBL307639 IC50 = 5200.0 nM 5.28
CHEMBL275084 ISOBUTYLMETHYLXANTHINE IC50 = 6300.0 nM 5.20
CHEMBL309026 IC50 = 8400.0 nM 5.08
CHEMBL367399 IC50 = 15000.0 nM 4.82
CHEMBL171957 IC50 = 19000.0 nM 4.72
CHEMBL175370 IC50 = 20000.0 nM 4.70
CHEMBL367083 IC50 = 36000.0 nM 4.44
CHEMBL366822 IC50 = 36000.0 nM 4.44
CHEMBL306389 IC50 = 40000.0 nM 4.40
CHEMBL175132 IC50 = 41000.0 nM 4.39
CHEMBL175958 IC50 = 54000.0 nM 4.27
CHEMBL20613 IC50 = 86000.0 nM 4.07
CHEMBL369824 IC50 > 50000.0 nM -
CHEMBL173998 IC50 > 25000.0 nM -
CHEMBL175489 IC50 > 25000.0 nM -