Compound Detail
CHEMBL175238
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL175238 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FOPGTHUTXLURMJ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
362.4
MW (Da)
2.75
ALogP
6
HBA
0
HBD
61.8
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 1 CHEMBL2095150 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase CHEMBL2652 | IC50 | 4.85 | 4.85 | 14000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 1 | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of Calmodulin Sensitive Phosphodiesterase 1 from pig coronary artery | 2423691 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | IC50 | = | 14000.0 | nM | 4.85 | Inhibition of Phosphodiesterase 2 from pig coronary artery | 2423691 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2423691 | 10.1021/jm00156a013 | Phosphodiesterase 1 | 1 |
| 2423691 | 10.1021/jm00156a013 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine