Assay Detail
Binding
CHEMBL768659
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Inhibition of Phosphodiesterase 2 from pig coronary artery
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Coronary artery |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of cyclic nucleotide phosphodiesterases from pig coronary artery by benzo-separated analogues of 3-isobutyl-1-methylxanthine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.55 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175370 | — | — | 1 | 4.89 |
| CHEMBL175238 | — | — | 1 | 4.85 |
| CHEMBL171957 | — | — | 1 | 4.85 |
| CHEMBL20613 | — | — | 1 | 4.77 |
| CHEMBL309026 | — | — | 1 | 4.75 |
| CHEMBL175489 | — | — | 1 | 4.72 |
| CHEMBL173998 | — | — | 1 | 4.70 |
| CHEMBL366545 | — | — | 1 | 4.57 |
| CHEMBL369824 | — | — | 1 | 4.36 |
| CHEMBL177336 | — | — | 1 | 4.24 |
| CHEMBL175958 | — | — | 1 | 4.18 |
| CHEMBL277529 | — | — | 1 | 4.17 |
| CHEMBL306389 | — | — | 1 | 4.05 |
| CHEMBL367399 | — | — | 1 | - |
| CHEMBL366822 | — | — | 1 | - |
| CHEMBL26606 | — | — | 1 | - |
| CHEMBL175132 | — | — | 1 | - |
| CHEMBL307639 | — | — | 1 | - |
| CHEMBL367083 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175370 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL175238 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL171957 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL20613 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL309026 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL175489 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL173998 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL366545 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL369824 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL177336 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL175958 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL277529 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL306389 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL367399 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL366822 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL26606 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL175132 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL307639 | — | IC50 | = | 212000.0 | nM | - |
| CHEMBL367083 | — | IC50 | > | 50000.0 | nM | - |