Assay Detail
Functional
CHEMBL768979
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Test against PAF-induced aggregation of rabbit platelets in vitro
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 5.06 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352680 | — | — | 1 | 6.22 |
| CHEMBL159417 | — | — | 1 | 6.10 |
| CHEMBL159054 | — | — | 1 | 5.85 |
| CHEMBL440367 | — | — | 1 | 5.72 |
| CHEMBL161575 | — | — | 1 | 5.70 |
| CHEMBL158583 | — | — | 1 | 5.70 |
| CHEMBL354012 | — | — | 1 | 5.70 |
| CHEMBL161233 | — | — | 1 | 5.70 |
| CHEMBL161469 | — | — | 1 | 5.70 |
| CHEMBL161676 | — | — | 1 | 5.70 |
| CHEMBL161654 | — | — | 1 | 5.66 |
| CHEMBL162647 | — | — | 1 | 5.62 |
| CHEMBL161729 | — | — | 1 | 5.58 |
| CHEMBL161513 | — | — | 1 | 5.55 |
| CHEMBL423785 | — | — | 1 | 5.48 |
| CHEMBL162195 | — | — | 1 | 5.38 |
| CHEMBL161591 | — | — | 1 | 5.38 |
| CHEMBL159363 | — | — | 1 | 5.37 |
| CHEMBL348539 | — | — | 1 | 5.32 |
| CHEMBL158098 | — | — | 1 | 5.23 |
| CHEMBL350328 | — | — | 1 | 5.21 |
| CHEMBL423606 | — | — | 1 | 5.16 |
| CHEMBL158099 | — | — | 1 | 5.12 |
| CHEMBL161822 | — | — | 1 | 5.04 |
| CHEMBL161089 | — | — | 1 | 5.02 |
| CHEMBL160201 | — | — | 1 | 4.70 |
| CHEMBL162586 | — | — | 1 | 4.66 |
| CHEMBL351670 | — | — | 1 | 4.66 |
| CHEMBL161464 | — | — | 1 | 4.60 |
| CHEMBL162638 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352680 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL159417 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL159054 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL440367 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL161575 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL158583 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL354012 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL161233 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL161469 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL161676 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL161654 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL162647 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL161729 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL161513 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL423785 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL162195 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL161591 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL159363 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL348539 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL158098 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL350328 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL423606 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL158099 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL161822 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL161089 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL160201 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL351670 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL162586 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL161464 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL162638 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL161161 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL161804 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL159099 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL162359 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL157537 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL159511 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL161662 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL157638 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL157994 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL435656 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL161736 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL159095 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL511 | PYRILAMINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL352162 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL161732 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL158820 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL534 | KETOTIFEN | IC50 | > | 100000.0 | nM | - |
| CHEMBL157582 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL639 | AZELASTINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL162537 | — | IC50 | > | 100000.0 | nM | - |