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Assay Detail

CHEMBL769172

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of protein kinase C
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Protein kinase C (PKC) (CHEMBL2094266)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

The synthesis and evaluation of diacylglycerol analogues as potential second-messenger antagonists
Briggs JC, Dawson AP, Gibson I, Haines AH, Hook J, Lloyd A, Meiners S, Taylor RJ
Bioorg Med Chem Lett (1992) 2 : 127 -130
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 4.67 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL24609 MONOCTANOIN COMPONENT C -1.0 1 5.00
CHEMBL26341 1 5.00
CHEMBL26440 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL24609 MONOCTANOIN COMPONENT C IC50 = 10000.0 nM 5.00
CHEMBL26341 IC50 = 10000.0 nM 5.00
CHEMBL26440 IC50 = 100000.0 nM 4.00