Compound Detail
CHEMBL24609
MONOCTANOIN COMPONENT C Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL24609 |
| Name | MONOCTANOIN COMPONENT C |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZQBULZYTDGUSSK-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
3
Known Names
Molecular Properties
344.5
MW (Da)
4.15
ALogP
5
HBA
1
HBD
72.8
PSA (Ų)
0.34
QED
0
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
Ki 2 meas. best 7.84
IC50 1 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C eta type CHEMBL4992 | Ki | 7.84 | 7.84 | 14.5 | 1 |
| Protein kinase C gamma type CHEMBL3604 | Ki | 5.53 | 5.53 | 2930.0 | 1 |
| Protein kinase C (PKC) CHEMBL2094266 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C eta type | Ki | = | 14.5 | nM | 7.84 | Inhibition of [3H]- PDBu binding to peptide D of mouse skin Protein kinase C eta | - |
| Protein kinase C gamma type | Ki | = | 2930.0 | nM | 5.53 | Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gamma | - |
| Protein kinase C (PKC) | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of protein kinase C | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)80433-9 | Protein kinase C (PKC) | 1 |
| - | 10.1016/S0960-894X(01)80433-9 | MR4 | 1 |
| - | 10.1016/S0960-894X(01)80433-9 | HT-29 | 1 |
| - | 10.1016/0960-894X(96)00026-1 | Protein kinase C gamma type | 1 |
| - | 10.1016/0960-894X(96)00026-1 | Protein kinase C eta type | 1 |
Data from ChEMBL 36 via Core Engine