Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL769200

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Protein phosphatase 2B
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structure-based design of novel calcineurin (PP2B) inhibitors
Tatlock JH, Angelica Linton M, Hou XJ, Kissinger CR, Pelletier LA, Showalter RE, Tempczyk A, Ernest Villafranca J
Bioorg Med Chem Lett (1997) 7 : 1007 -1012
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 5.60 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL7026 1 6.30
CHEMBL266327 1 6.00
CHEMBL268402 1 5.92
CHEMBL7636 1 5.85
CHEMBL7036 1 5.75
CHEMBL7433 1 5.70
CHEMBL427979 1 5.64
CHEMBL7451 1 5.43
CHEMBL269101 1 5.13
CHEMBL6951 1 4.96
CHEMBL428650 ENDOTHALL 1 4.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL7026 Ki = 500.0 nM 6.30
CHEMBL266327 Ki = 1000.0 nM 6.00
CHEMBL268402 Ki = 1200.0 nM 5.92
CHEMBL7636 Ki = 1400.0 nM 5.85
CHEMBL7036 Ki = 1800.0 nM 5.75
CHEMBL7433 Ki = 2000.0 nM 5.70
CHEMBL427979 Ki = 2300.0 nM 5.64
CHEMBL7451 Ki = 3700.0 nM 5.43
CHEMBL269101 Ki = 7400.0 nM 5.13
CHEMBL6951 Ki = 11000.0 nM 4.96
CHEMBL428650 ENDOTHALL Ki = 11500.0 nM 4.94