Assay Detail
Functional
CHEMBL769855
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of platelet derived growth factor (PDGF) stimulated PDGF-receptor autophosphorylation in rat aortic vascular smooth muscle cells (RAVSMCs)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor (PDGFr) (CHEMBL2111344) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.04 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301483 | — | — | 1 | 6.60 |
| CHEMBL57347 | — | — | 1 | 6.57 |
| CHEMBL45827 | — | — | 1 | 6.35 |
| CHEMBL57366 | — | — | 1 | 6.20 |
| CHEMBL299026 | — | — | 1 | 5.75 |
| CHEMBL432738 | — | — | 1 | 5.43 |
| CHEMBL75188 | — | — | 1 | 5.37 |
| CHEMBL299763 | — | — | 1 | - |
| CHEMBL56236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301483 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL57347 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL45827 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL57366 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL299026 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL432738 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL75188 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL299763 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL56236 | — | IC50 | > | 50000.0 | nM | - |