Assay Detail
Functional
CHEMBL770049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the concentration that causes 50% relaxation when contraction in rabbit aorta was induced by 3 x 10 E -8 M of U-46619.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Azulene derivatives: new non-prostanoid thromboxane A2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.92 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262655 | — | — | 1 | 7.64 |
| CHEMBL77223 | — | — | 1 | 7.01 |
| CHEMBL78123 | — | — | 1 | 6.82 |
| CHEMBL77097 | — | — | 1 | 6.37 |
| CHEMBL74674 | — | — | 1 | 5.96 |
| CHEMBL8273 | SULOTROBAN | 2.0 | 1 | 5.89 |
| CHEMBL75309 | — | — | 1 | 5.80 |
| CHEMBL311633 | — | — | 1 | 5.52 |
| CHEMBL75089 | — | — | 1 | 5.47 |
| CHEMBL76825 | — | — | 1 | 4.85 |
| CHEMBL443795 | — | — | 1 | 4.85 |
| CHEMBL441057 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262655 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL77223 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL78123 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL77097 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL74674 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL8273 | SULOTROBAN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL75309 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL311633 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL75089 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL76825 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL443795 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL441057 | — | IC50 | = | 16000.0 | nM | 4.80 |