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Assay Detail

CHEMBL770106

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Binding
Inhibitory concentration against recombinant human cAMP-dependent Protein kinase A
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

cAMP-dependent protein kinase catalytic subunit alpha (CHEMBL4101)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety.
Lai YS, Mendoza JS, Jagdmann GE, Menaldino DS, Biggers CK, Heerding JM, Wilson JW, Hall SE, Jiang JB, Janzen WP, Ballas LM.
J Med Chem (1997) 40 : 226 -235
PubMed 9003521 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 6.03 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL52529 1 7.52
CHEMBL432168 1 7.30
CHEMBL60254 BALANOL 1 7.30
CHEMBL59828 1 7.16
CHEMBL308263 1 7.05
CHEMBL306580 1 6.89
CHEMBL307708 1 6.77
CHEMBL75004 1 6.66
CHEMBL75661 1 6.64
CHEMBL309034 1 6.60
CHEMBL67442 1 6.46
CHEMBL306373 1 6.35
CHEMBL304549 1 5.85
CHEMBL78129 1 5.77
CHEMBL80525 1 5.72
CHEMBL262980 1 5.58
CHEMBL312067 1 5.52
CHEMBL441802 1 5.44
CHEMBL306623 1 5.35
CHEMBL77970 1 5.28
CHEMBL76537 1 5.12
CHEMBL77399 1 4.89
CHEMBL309078 1 4.58
CHEMBL263910 1 4.50
CHEMBL305718 1 4.42
CHEMBL76920 1 -
CHEMBL306883 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL52529 IC50 = 30.0 nM 7.52
CHEMBL432168 IC50 = 50.0 nM 7.30
CHEMBL60254 BALANOL IC50 = 50.0 nM 7.30
CHEMBL59828 IC50 = 70.0 nM 7.16
CHEMBL308263 IC50 = 90.0 nM 7.05
CHEMBL306580 IC50 = 130.0 nM 6.89
CHEMBL307708 IC50 = 170.0 nM 6.77
CHEMBL75004 IC50 = 220.0 nM 6.66
CHEMBL75661 IC50 = 230.0 nM 6.64
CHEMBL309034 IC50 = 250.0 nM 6.60
CHEMBL67442 IC50 = 350.0 nM 6.46
CHEMBL306373 IC50 = 450.0 nM 6.35
CHEMBL304549 IC50 = 1400.0 nM 5.85
CHEMBL78129 IC50 = 1700.0 nM 5.77
CHEMBL80525 IC50 = 1900.0 nM 5.72
CHEMBL262980 IC50 = 2600.0 nM 5.58
CHEMBL312067 IC50 = 3000.0 nM 5.52
CHEMBL441802 IC50 = 3600.0 nM 5.44
CHEMBL306623 IC50 = 4500.0 nM 5.35
CHEMBL77970 IC50 = 5200.0 nM 5.28
CHEMBL76537 IC50 = 7500.0 nM 5.12
CHEMBL77399 IC50 = 13000.0 nM 4.89
CHEMBL309078 IC50 = 26000.0 nM 4.58
CHEMBL263910 IC50 = 32000.0 nM 4.50
CHEMBL305718 IC50 = 38000.0 nM 4.42
CHEMBL76920 IC50 < 330.0 nM -
CHEMBL306883 IC50 > 50000.0 nM -