Assay Detail
Binding
CHEMBL770309
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Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.28 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309907 | — | — | 1 | 8.40 |
| CHEMBL55675 | — | — | 1 | 8.07 |
| CHEMBL79460 | — | — | 1 | 8.05 |
| CHEMBL56593 | — | — | 1 | 8.04 |
| CHEMBL55454 | — | — | 1 | 8.03 |
| CHEMBL79410 | — | — | 1 | 7.97 |
| CHEMBL81839 | — | — | 1 | 7.96 |
| CHEMBL310202 | — | — | 1 | 7.96 |
| CHEMBL56540 | — | — | 1 | 7.94 |
| CHEMBL299952 | — | — | 1 | 7.88 |
| CHEMBL311300 | PELDESINE | 2.0 | 1 | 7.87 |
| CHEMBL79784 | — | — | 1 | 7.81 |
| CHEMBL82087 | — | — | 1 | 7.78 |
| CHEMBL81055 | — | — | 1 | 7.73 |
| CHEMBL310364 | — | — | 1 | 7.72 |
| CHEMBL79865 | — | — | 1 | 7.59 |
| CHEMBL285627 | — | — | 1 | 7.45 |
| CHEMBL83158 | — | — | 1 | 7.42 |
| CHEMBL81966 | — | — | 1 | 7.19 |
| CHEMBL78808 | — | — | 1 | 7.18 |
| CHEMBL309679 | — | — | 1 | 7.08 |
| CHEMBL81731 | — | — | 1 | 6.96 |
| CHEMBL79132 | — | — | 1 | 6.83 |
| CHEMBL54489 | — | — | 1 | 6.47 |
| CHEMBL301203 | — | — | 1 | 6.06 |
| CHEMBL292132 | — | — | 1 | 6.05 |
| CHEMBL8040 | 8-AMINOGUANINE | — | 1 | 6.01 |
| CHEMBL311528 | — | — | 1 | 4.99 |
| CHEMBL415041 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309907 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL55675 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL79460 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL56593 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL55454 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL79410 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL81839 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL310202 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL56540 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL299952 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL311300 | PELDESINE | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL79784 | — | Ki | = | 15.6 | nM | 7.81 |
| CHEMBL82087 | — | Ki | = | 16.5 | nM | 7.78 |
| CHEMBL81055 | — | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL310364 | — | Ki | = | 18.9 | nM | 7.72 |
| CHEMBL79865 | — | Ki | = | 25.4 | nM | 7.59 |
| CHEMBL285627 | — | Ki | = | 35.7 | nM | 7.45 |
| CHEMBL83158 | — | Ki | = | 37.8 | nM | 7.42 |
| CHEMBL81966 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL78808 | — | Ki | = | 66.7 | nM | 7.18 |
| CHEMBL309679 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL81731 | — | Ki | = | 109.1 | nM | 6.96 |
| CHEMBL79132 | — | Ki | = | 148.8 | nM | 6.83 |
| CHEMBL54489 | — | Ki | = | 335.3 | nM | 6.47 |
| CHEMBL301203 | — | Ki | = | 862.0 | nM | 6.06 |
| CHEMBL292132 | — | Ki | = | 885.0 | nM | 6.05 |
| CHEMBL8040 | 8-AMINOGUANINE | Ki | = | 982.0 | nM | 6.01 |
| CHEMBL311528 | — | Ki | = | 10321.0 | nM | 4.99 |
| CHEMBL415041 | — | Ki | = | 24645.0 | nM | 4.61 |