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Compound Detail

CHEMBL55675

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Nc1nc(O)c2[nH]cc(CC3CCCS3)c2n1

Basic Information

ChEMBL ID CHEMBL55675
Phase Preclinical
Structure Type MOL
InChI Key YYFKQPPPFQYGFO-UHFFFAOYSA-N
1
Targets
5
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

250.3
MW (Da)
1.68
ALogP
5
HBA
3
HBD
87.8
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H14N4OS
MW 250.33
Aromatic Rings 2
Heavy Atoms 17
NP-Likeness 0.08

Activity Summary

IC50 3 meas. best 7.96
Ki 2 meas. best 8.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Purine nucleoside phosphorylase
CHEMBL2935
Ki 8.22 8.145 6.0 2
Purine nucleoside phosphorylase
CHEMBL2935
IC50 7.96 7.46 11.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10395483 10.1021/jm990037y Purine nucleoside phosphorylase 5
8515423 10.1021/jm00065a007 Purine nucleoside phosphorylase 3

Data from ChEMBL 36 via Core Engine