Assay Detail
Binding
CHEMBL873419
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Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using 2-amino-6-mercapto-7-methyl purine ribonucleoside (MESG) as substrate.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.61 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82087 | — | — | 1 | 8.77 |
| CHEMBL311300 | PELDESINE | 2.0 | 1 | 8.51 |
| CHEMBL56540 | — | — | 1 | 8.48 |
| CHEMBL79784 | — | — | 1 | 8.46 |
| CHEMBL310202 | — | — | 1 | 8.44 |
| CHEMBL55454 | — | — | 1 | 8.41 |
| CHEMBL310364 | — | — | 1 | 8.37 |
| CHEMBL81839 | — | — | 1 | 8.34 |
| CHEMBL81055 | — | — | 1 | 8.27 |
| CHEMBL55675 | — | — | 1 | 8.22 |
| CHEMBL56593 | — | — | 1 | 8.21 |
| CHEMBL299952 | — | — | 1 | 8.19 |
| CHEMBL81966 | — | — | 1 | 7.84 |
| CHEMBL79865 | — | — | 1 | 7.77 |
| CHEMBL83158 | — | — | 1 | 7.69 |
| CHEMBL285627 | — | — | 1 | 7.68 |
| CHEMBL309907 | — | — | 1 | 7.66 |
| CHEMBL309679 | — | — | 1 | 7.50 |
| CHEMBL81731 | — | — | 1 | 7.46 |
| CHEMBL78808 | — | — | 1 | 7.45 |
| CHEMBL79460 | — | — | 1 | 7.21 |
| CHEMBL79132 | — | — | 1 | 7.17 |
| CHEMBL54489 | — | — | 1 | 6.48 |
| CHEMBL301203 | — | — | 1 | 6.30 |
| CHEMBL8040 | 8-AMINOGUANINE | — | 1 | 6.17 |
| CHEMBL292132 | — | — | 1 | 6.12 |
| CHEMBL311528 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82087 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL311300 | PELDESINE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL56540 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL79784 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL310202 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL55454 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL310364 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL81839 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL81055 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL55675 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL56593 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL299952 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL81966 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL79865 | — | Ki | = | 16.9 | nM | 7.77 |
| CHEMBL83158 | — | Ki | = | 20.3 | nM | 7.69 |
| CHEMBL285627 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL309907 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL309679 | — | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL81731 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL78808 | — | Ki | = | 35.6 | nM | 7.45 |
| CHEMBL79460 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL79132 | — | Ki | = | 67.7 | nM | 7.17 |
| CHEMBL54489 | — | Ki | = | 332.7 | nM | 6.48 |
| CHEMBL301203 | — | Ki | = | 500.3 | nM | 6.30 |
| CHEMBL8040 | 8-AMINOGUANINE | Ki | = | 680.6 | nM | 6.17 |
| CHEMBL292132 | — | Ki | = | 766.0 | nM | 6.12 |
| CHEMBL311528 | — | Ki | = | 67501.0 | nM | 4.17 |