Assay Detail
Functional
CHEMBL770558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to antagonise the contractile effects of the selective NK2 receptor agonist [B-ala8]NKA in the rabbit pulmonary artery (RPA)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
4-Amino-2-(aryl)-butylbenzamides and Their conformationally constrained analogues. Potent antagonists of the human neurokinin-2 (NK(2)) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 8.19 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71397 | — | — | 1 | 9.50 |
| CHEMBL56835 | — | — | 1 | 9.10 |
| CHEMBL71647 | — | — | 1 | 8.90 |
| CHEMBL305236 | — | — | 1 | 8.60 |
| CHEMBL74127 | — | — | 1 | 8.40 |
| CHEMBL69889 | — | — | 1 | 8.40 |
| CHEMBL68440 | — | — | 1 | 8.40 |
| CHEMBL68917 | — | — | 1 | 8.30 |
| CHEMBL71644 | — | — | 1 | 8.10 |
| CHEMBL308901 | — | — | 1 | 7.70 |
| CHEMBL71704 | — | — | 1 | 7.60 |
| CHEMBL304807 | — | — | 1 | 7.30 |
| CHEMBL70157 | — | — | 1 | 7.20 |
| CHEMBL305191 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71397 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL56835 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL71647 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL305236 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL74127 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL69889 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL68440 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL68917 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL71644 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL308901 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL71704 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL304807 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL70157 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL305191 | — | Kd | = | 79.43 | nM | 7.10 |