Assay Detail
Functional
CHEMBL770615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
pA2 value was determined by the compound's ability to antagonize the AII-induced contraction of rabbit aorta rings.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide angiotensin II receptor antagonists: synthetic and computational chemistry of N-[[4-[2-(2H-tetrazol-5-yl)-1-cycloalken-1- yl]phenyl]methyl]imidazole derivatives and their in vitro activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.73 | 9.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 9.63 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.42 |
| CHEMBL88350 | — | — | 1 | 8.39 |
| CHEMBL314220 | — | — | 1 | 7.92 |
| CHEMBL89216 | — | — | 1 | 7.84 |
| CHEMBL314149 | — | — | 1 | 6.89 |
| CHEMBL89403 | — | — | 1 | 6.45 |
| CHEMBL328552 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | Kd | = | 0.2344 | nM | 9.63 |
| CHEMBL191 | LOSARTAN | Kd | = | 3.802 | nM | 8.42 |
| CHEMBL88350 | — | Kd | = | 4.074 | nM | 8.39 |
| CHEMBL314220 | — | Kd | = | 12.02 | nM | 7.92 |
| CHEMBL89216 | — | Kd | = | 14.45 | nM | 7.84 |
| CHEMBL314149 | — | Kd | = | 128.82 | nM | 6.89 |
| CHEMBL89403 | — | Kd | = | 354.81 | nM | 6.45 |
| CHEMBL328552 | — | Kd | = | 467.74 | nM | 6.33 |