Assay Detail
Functional
CHEMBL770633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PAF-induced rabbit platelet aggregation
42
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3',4',5'-trimethoxybenzoyl)-2-[[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.29 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6270 | — | — | 3 | 7.40 |
| CHEMBL6203 | — | — | 3 | 7.10 |
| CHEMBL258053 | — | — | 1 | 7.10 |
| CHEMBL269133 | — | — | 1 | 7.00 |
| CHEMBL269134 | — | — | 1 | 7.00 |
| CHEMBL268596 | — | — | 3 | 7.00 |
| CHEMBL6232 | — | — | 1 | 6.92 |
| CHEMBL6359 | — | — | 1 | 6.89 |
| CHEMBL380444 | — | — | 1 | 6.89 |
| CHEMBL6202 | — | — | 1 | 6.85 |
| CHEMBL332848 | — | — | 1 | 6.77 |
| CHEMBL269340 | — | — | 1 | 6.62 |
| CHEMBL269132 | — | — | 1 | 6.55 |
| CHEMBL258253 | — | — | 1 | 6.54 |
| CHEMBL268597 | — | — | 1 | 6.54 |
| CHEMBL1793831 | — | — | 1 | 6.52 |
| CHEMBL6211 | — | — | 1 | 6.51 |
| CHEMBL266886 | — | — | 1 | 6.50 |
| CHEMBL24879 | — | — | 1 | 6.43 |
| CHEMBL269131 | — | — | 1 | 6.42 |
| CHEMBL6341 | — | — | 1 | 6.38 |
| CHEMBL6217 | — | — | 1 | 6.37 |
| CHEMBL204022 | — | — | 1 | 6.33 |
| CHEMBL514432 | GINKOLIDE B | — | 1 | 6.13 |
| CHEMBL6319 | — | — | 1 | 5.90 |
| CHEMBL6244 | — | — | 1 | 5.75 |
| CHEMBL414007 | — | — | 1 | 5.57 |
| CHEMBL266184 | — | — | 1 | 5.55 |
| CHEMBL6350 | — | — | 1 | 5.41 |
| CHEMBL265773 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6270 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL6270 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL6270 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL6203 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL258053 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL268596 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL269133 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL269134 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL268596 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL268596 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL6232 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL380444 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL6359 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL6202 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL332848 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL6203 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL269340 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL269132 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL258253 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL268597 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1793831 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL6211 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL266886 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL24879 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL269131 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL6341 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL6217 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL204022 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL514432 | GINKOLIDE B | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL6203 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL6319 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL6244 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL414007 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL266184 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL6350 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL265773 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL414696 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL6263 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL267229 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL267357 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL6322 | PMS-601 | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL227457 | — | IC50 | = | 45000.0 | nM | 4.35 |