Compound Detail
CHEMBL6244
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL6244 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RSMOCRIXTHPCBX-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
474.5
MW (Da)
2.34
ALogP
8
HBA
0
HBD
96.0
PSA (Ų)
0.58
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oryctolagus cuniculus CHEMBL374 | IC50 | 5.75 | 5.75 | 1780.0 | 1 |
| Platelet-activating factor receptor CHEMBL5136 | IC50 | 5.75 | 5.39 | 1780.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-activating factor receptor | IC50 | = | 1780.0 | nM | 5.75 | Inhibition of PAF-induced rabbit platelet aggregation | 8478911 |
| Oryctolagus cuniculus | IC50 | = | 1780.0 | nM | 5.75 | Inhibition of PAF-induced platelet aggregation was determined using platelet ric... | 10841793 |
| Platelet-activating factor receptor | IC50 | = | 9400.0 | nM | 5.03 | Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-An... | 1433215 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1433215 | 10.1021/jm00100a018 | Platelet-activating factor receptor | 3 |
| 10841793 | 10.1021/jm9911276 | Human immunodeficiency virus 1 | 2 |
| 8478911 | 10.1021/jm00060a006 | Platelet-activating factor receptor | 1 |
| 10841793 | 10.1021/jm9911276 | Oryctolagus cuniculus | 1 |
Data from ChEMBL 36 via Core Engine