Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL770635

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory effect on PGE-2 production in LPS-stimulated RAW264.7 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Intermediate

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

Styrylheterocycles as a novel class inhibitor of cyclooxygenase-2-mediated prostaglandin E(2) production.
Lee SK, Park EJ, Lee E, Min HY, Kim EY, Lee T, Kim S.
Bioorg Med Chem Lett (2004) 14 : 2105 -2108
PubMed 15080988 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.83 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL304791 1 7.00
CHEMBL67296 1 6.40
CHEMBL68138 1 6.30
CHEMBL303375 1 6.00
CHEMBL43013 1 5.92
CHEMBL43396 1 5.89
CHEMBL67844 1 5.82
CHEMBL304890 1 5.82
CHEMBL65214 1 5.51
CHEMBL165 RESVERATROL 3.0 1 5.40
CHEMBL43395 1 5.39
CHEMBL63960 1 5.24
CHEMBL63443 1 5.13
CHEMBL441035 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL304791 IC50 = 100.0 nM 7.00
CHEMBL67296 IC50 = 400.0 nM 6.40
CHEMBL68138 IC50 = 500.0 nM 6.30
CHEMBL303375 IC50 = 1000.0 nM 6.00
CHEMBL43013 IC50 = 1200.0 nM 5.92
CHEMBL43396 IC50 = 1300.0 nM 5.89
CHEMBL67844 IC50 = 1500.0 nM 5.82
CHEMBL304890 IC50 = 1500.0 nM 5.82
CHEMBL65214 IC50 = 3100.0 nM 5.51
CHEMBL165 RESVERATROL IC50 = 4000.0 nM 5.40
CHEMBL43395 IC50 = 4100.0 nM 5.39
CHEMBL63960 IC50 = 5800.0 nM 5.24
CHEMBL63443 IC50 = 7400.0 nM 5.13
CHEMBL441035 IC50 > 33300.0 nM -