Assay Detail
Functional
CHEMBL770662
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Ability to stimulate contraction of the rabbit iris sphincter smooth muscle using smooth muscle contraction assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Use of beta-methylphenylalanine (beta MeF) residues to probe the nature of the interaction of substance P with its receptor: effects of beta MeF-containing substance P analogs on rabbit iris smooth muscle contraction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 9.15 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3037872 | — | — | 1 | 9.89 |
| CHEMBL2371143 | — | — | 1 | 9.74 |
| CHEMBL2369908 | — | — | 1 | 9.55 |
| CHEMBL2369917 | — | — | 1 | 9.27 |
| CHEMBL2369911 | — | — | 1 | 9.24 |
| CHEMBL2369913 | — | — | 1 | 9.23 |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 9.21 |
| CHEMBL2369916 | — | — | 1 | 8.24 |
| CHEMBL2369919 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3037872 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL2371143 | — | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL2369908 | — | EC50 | = | 0.28 | nM | 9.55 |
| CHEMBL2369917 | — | EC50 | = | 0.54 | nM | 9.27 |
| CHEMBL2369911 | — | EC50 | = | 0.58 | nM | 9.24 |
| CHEMBL2369913 | — | EC50 | = | 0.59 | nM | 9.23 |
| CHEMBL235363 | SUBSTANCE P | EC50 | = | 0.61 | nM | 9.21 |
| CHEMBL2369916 | — | EC50 | = | 5.76 | nM | 8.24 |
| CHEMBL2369919 | — | EC50 | = | 10.0 | nM | 8.00 |