Assay Detail
Functional
CHEMBL770813
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Compound was tested for inhibition of U-46,619 induced contraction of isolated rabbit saphenous vein
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Saphenous vein |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 20 | 9.22 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281036 | — | — | 1 | 11.00 |
| CHEMBL281545 | — | — | 1 | 10.80 |
| CHEMBL448096 | — | — | 1 | 10.60 |
| CHEMBL27856 | — | — | 1 | 10.10 |
| CHEMBL9937 | — | — | 1 | 9.90 |
| CHEMBL28076 | — | — | 1 | 9.60 |
| CHEMBL29374 | — | — | 1 | 9.40 |
| CHEMBL28978 | — | — | 1 | 9.30 |
| CHEMBL283705 | — | — | 1 | 9.20 |
| CHEMBL280602 | — | — | 1 | 9.10 |
| CHEMBL28552 | — | — | 1 | 9.00 |
| CHEMBL28704 | — | — | 1 | 8.90 |
| CHEMBL418394 | — | — | 1 | 8.90 |
| CHEMBL29240 | — | — | 3 | 8.90 |
| CHEMBL30024 | — | — | 1 | 8.60 |
| CHEMBL28014 | — | — | 1 | 8.10 |
| CHEMBL29375 | — | — | 1 | 7.90 |
| CHEMBL361812 | RAMATROBAN | 4.0 | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281036 | — | Kd | = | 0.01 | nM | 11.00 |
| CHEMBL281545 | — | Kd | = | 0.01585 | nM | 10.80 |
| CHEMBL448096 | — | Kd | = | 0.02512 | nM | 10.60 |
| CHEMBL27856 | — | Kd | = | 0.07943 | nM | 10.10 |
| CHEMBL9937 | — | Kd | = | 0.1259 | nM | 9.90 |
| CHEMBL28076 | — | Kd | = | 0.2512 | nM | 9.60 |
| CHEMBL29374 | — | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL28978 | — | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL283705 | — | Kd | = | 0.631 | nM | 9.20 |
| CHEMBL280602 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL28552 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL418394 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL28704 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL29240 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL29240 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL30024 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL29240 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL28014 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL29375 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL361812 | RAMATROBAN | Kd | = | 12.59 | nM | 7.90 |